منابع مشابه
Brain pathology contributes to simultaneous change in physical frailty and cognition in old age.
OBJECTIVE First, we tested the hypothesis that the rate of change of physical frailty and cognitive function in older adults are correlated. Next, we examined if their rates of change are associated with the same brain pathologies. METHODS About 2,167 older adults participating in the Religious Orders Study and the Rush Memory and Aging Project had annual clinical evaluations. Bivariate rando...
متن کاملLinking cognition and frailty in middle and old age: metabolic syndrome matters.
OBJECTIVES This study examined whether metabolic syndrome (MetS) would moderate the association of cognition with frailty in middle and old age. METHODS A cross-sectional design was used. Six hundred and ninety participants (age ≥ 50 years) from an on-going national survey were included in the study. Confirmatory factor analysis was applied to determine latent variables of executive function ...
متن کاملDeterminants of musculoskeletal frailty and the risk of falls in old age.
Neuromuscular parameters that describe locomotion are indispensable variables for the diagnosis and treatment of frailty, fall risk and osteoporosis. A scientifically-based standardized locomotor assessment should be an essential part of medical examinations in research and clinical practice. There has been no previous consensus regarding which test procedures should be included in a locomotor ...
متن کاملLeisure-time physical activity in midlife is related to old age frailty.
BACKGROUND There are scarce studies of the long-term associations between leisure-time physical activity (LTPA) in midlife and phenotypic frailty in old age. METHODS We studied healthy Caucasian men of high socioeconomic status (N = 514), who had participated in health checkups during the 1960s (the Helsinki Businessmen Study, Finland). In 1974, they were examined with questionnaires and clin...
متن کاملJAK inhibition alleviates the cellular senescence-associated secretory phenotype and frailty in old age.
Chronic, low grade, sterile inflammation frequently accompanies aging and age-related diseases. Cellular senescence is associated with the production of proinflammatory chemokines, cytokines, and extracellular matrix (ECM) remodeling proteases, which comprise the senescence-associated secretory phenotype (SASP). We found a higher burden of senescent cells in adipose tissue with aging. Senescent...
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ژورنال
عنوان ژورنال: British Journal of General Practice
سال: 2009
ISSN: 0960-1643,1478-5242
DOI: 10.3399/bjgp09x453846